Pseudomonas aeruginosa Strain-sharing in Early Infection Among Children With Cystic Fibrosis.

ABSTRACT:

Background

We previously identified Pseudomonas aeruginosa isolates with characteristics typical of chronic infection in some early infections in children with cystic fibrosis (CF), suggesting that these isolates may have been acquired from other patients. Our objective was to define the extent of P. aeruginosa strain-sharing in early CF infections and its impact on antibiotic eradication treatment failure rates.

Methods

We performed whole genome sequencing on isolates from early pediatric CF pulmonary infections and from the following comparator groups in the same hospital: chronic CF infection, sink drains, sterile site infections, and asymptomatic carriage. Univariate logistic regression was used to assess factors associated with treatment failure.

Results

In this

SUBMITTER: Stapleton PJ 

PROVIDER: S-EPMC8563227 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature