Increased infectious-cause hospitalization among infants who are HIV-exposed uninfected compared with HIV-unexposed.

ABSTRACT:

Objectives

Increased risk of morbidity and hospitalization has been observed in children who are HIV-exposed uninfected (HEU) compared with HIV-unexposed uninfected (HUU). Studies in the era of universal maternal antiretroviral treatment (ART) are limited.

Design

Prospective cohort.

Methods

We investigated hospitalization between 29 days and 12 months of life in a South African cohort of infants born between February 2017 and January 2019 (HEU = 455; HUU = 458). All mothers known with HIV during pregnancy received ART. We reviewed hospital records and classified and graded infectious diagnoses using a standardized tool. We examined factors associated with infectious-cause hospitalization using mixed-effects Poisson regression.

Results

Infants HEU vs. HUU had hi

SUBMITTER: Anderson K 

PROVIDER: S-EPMC8563388 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature