Features of intracranial interictal epileptiform discharges associated with memory encoding.

ABSTRACT:

Objective

Interictal epileptiform discharges (IEDs) were shown to be associated with cognitive impairment in persons with epilepsy. Previous studies indicated that IED rate, location, timing, and spatial relation to the seizure onset zone could predict an IED's impact on memory encoding and retrieval if they occurred in lateral temporal, mesial temporal, or parietal regions. In this study, we explore the influence that other IED properties (e.g., amplitude, duration, white matter classification) have on memory performance. We were specifically interested in investigating the influence that lateral temporal IEDs have on memory encoding.

Methods

Two hundred sixty-one subjects with medication-refractory epilepsy undergoing intracranial electroencephalographic monitoring perform

SUBMITTER: Quon RJ 

PROVIDER: S-EPMC8563407 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature