Bone biomechanical properties and tissue-scale bone quality in a genetic mouse model of familial dysautonomia.

ABSTRACT:

Purpose

Familial dysautonomia (FD) is associated with a high prevalence of bone fractures, but the impacts of the disease on bone mass and quality are unclear. The purpose of this study was to evaluate tissue through whole-bone scale bone quality in a mouse model of FD.

Methods

Femurs from mature adult Tuba1a-Cre; Elp1^LoxP/LoxP conditional knockouts (CKO) (F = 7, M = 4) and controls (F = 5, M = 6) were evaluated for whole-bone flexural material properties, trabecular microarchitecture and cortical geometry, and areal bone mineral density (BMD). Adjacent maps spanning the thickness of femur midshaft cortical bone assessed tissue-scale modulus (nanoindentation), bone mineralization, mineral maturity, and collagen secondary structure (Raman spectroscopy).

Results<

SUBMITTER: Vahidi G 

PROVIDER: S-EPMC8563419 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature