Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study.

ABSTRACT:

Background

Native African men (NAM) experience a disproportionate burden of prostate cancer (PCa) and have higher mortality rates compared to European American men (EAM). While socioeconomic status has been implicated as a driver of this disparity, little is known about the genomic mechanisms and distinct biological pathways that are associated with PCa of native men of African origin.

Methods

To understand biological factors that contribute to this disparity we utilized a total of 406 multi-institutional localized PCa samples, collected by Men of African Descent and Carcinoma of the Prostate biospecimen network and Moffitt Cancer Center/University of Pennsylvania Health science system. We performed comparative genomics and immunohistochemistry to identify the biomarkers tha

SUBMITTER: Yamoah K 

PROVIDER: S-EPMC8563425 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature