Risedronate use to attenuate bone loss following sleeve gastrectomy: Results from a pilot randomized controlled trial.

ABSTRACT: The purpose of this study was to explore the efficacy of 150 mg once monthly oral risedronate use in the prevention of sleeve gastrectomy (SG) associated bone loss. Twenty-four SG patients (56 ± 7 years, 83% female, 21% black) were randomized to risedronate or placebo for 6 months, with an optional 12-month assessment. Outcome measures included 6 (n = 21) and 12 (n = 14) month change in dual energy x-ray absorptiometry-acquired regional areal bone mineral density (aBMD). Six-month treatment effect estimates [mean (95% CI)] revealed significant between group aBMD differences at the femoral neck [risedronate: +0.013 g/cm² (-0.021, 0.046) vs. placebo: -0.041 g/cm² (-0.067, -0.015)] and lumbar spine [risedronate: +0.028 g/cm² (-0.006, 0.063) vs. placebo: -0.029

SUBMITTER: Beavers KM 

PROVIDER: S-EPMC8563448 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature