Regulatory Network of PD1 Signaling Is Associated with Prognosis in Glioblastoma Multiforme.

ABSTRACT: Glioblastoma is an aggressive cancer of the brain and spine. While analysis of glioblastoma 'omics data has somewhat improved our understanding of the disease, it has not led to direct improvement in patient survival. Cancer survival is often characterized by differences in gene expression, but the mechanisms that drive these differences are generally unknown. We therefore set out to model the regulatory mechanisms associated with glioblastoma survival. We inferred individual patient gene regulatory networks using data from two different expression platforms from The Cancer Genome Atlas. We performed comparative network analysis between patients with long- and short-term survival. Seven pathways were identified as associated with survival, all of them involved in immune signaling; differen

SUBMITTER: Lopes-Ramos CM 

PROVIDER: S-EPMC8563450 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature