Fatigue in newly diagnosed acute myeloid leukaemia: general population comparison and predictive factors.

ABSTRACT:

Objectives

This study compared the burden of fatigue between treatment-naïve patients with newly diagnosed acute myeloid leukaemia (AML) and the general population and investigated patient factors associated with fatigue severity.

Methods

Pretreatment patient-reported fatigue was assessed with the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire in a sample of 463 newly diagnosed patients with AML who were enrolled in a clinical trial. Multivariable linear regression models were used to estimate the adjusted mean differences in fatigue between patients with AML and adults from the general population (n=847) by AML disease risk categories. A clinically meaningful difference in fatigue was defined as ≥3 points. Univariable and multivariable linear regress

SUBMITTER: Oswald LB 

PROVIDER: S-EPMC8563490 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature