Intraoperative neural signals predict rapid antidepressant effects of deep brain stimulation.

ABSTRACT: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is a promising intervention for treatment-resistant depression (TRD). Despite the failure of a clinical trial, multiple case series have described encouraging results, especially with the introduction of improved surgical protocols. Recent evidence further suggests that tractography targeting and intraoperative exposure to stimulation enhances early antidepressant effects that further evolve with ongoing chronic DBS. Accelerating treatment gains is critical to the care of this at-risk population, and identification of intraoperative electrophysiological biomarkers of early antidepressant effects will help guide future treatment protocols. Eight patients underwent intraoperative electrophysiological recording when bilateral DBS

SUBMITTER: Sendi MSE 

PROVIDER: S-EPMC8563808 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature