Autistic-Like Behavior and Impairment of Serotonin Transporter and AMPA Receptor Trafficking in N-Ethylmaleimide Sensitive Factor Gene-Deficient Mice.

ABSTRACT: Autism spectrum disorder (ASD), characterized by profound impairment in social interactions and communication skills, is the most common neurodevelopmental disorder. Many studies on the mechanisms underlying the development of ASD have focused on the serotonergic system; however, these studies have failed to completely elucidate the mechanisms. We previously identified N-ethylmaleimide-sensitive factor (NSF) as a new serotonin transporter (SERT)-binding protein and described its importance in SERT membrane trafficking and uptake in vitro. In the present study, we generated Nsf ^+/- mice and investigated their behavioral, neurotransmitter, and neurophysiological phenotypes in vivo. Nsf ^+/- mice exhibited abnormalities in

SUBMITTER: Xie MJ 

PROVIDER: S-EPMC8563833 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature