CD36 maintains the gastric mucosa and associates with gastric disease.

ABSTRACT: The gastric epithelium is often exposed to injurious elements and failure of appropriate healing predisposes to ulcers, hemorrhage, and ultimately cancer. We examined the gastric function of CD36, a protein linked to disease and homeostasis. We used the tamoxifen model of gastric injury in mice null for Cd36 (Cd36^-/-), with Cd36 deletion in parietal cells (PC-Cd36^-/-) or in endothelial cells (EC-Cd36^-/-). CD36 expresses on corpus ECs, on PC basolateral membranes, and in gastrin and ghrelin cells. Stomachs of Cd36^-/- mice have altered gland organization and secretion, more fibronectin, and inflammation. Tissue respiration and mitochondrial efficiency are reduced. Phospholipids increased and triglycerides decreased. Mucosal repair after injury is i

SUBMITTER: Jacome-Sosa M 

PROVIDER: S-EPMC8563937 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature