Short high fat diet triggers reversible and region specific effects in DCX⁺ hippocampal immature neurons of adolescent male mice.

ABSTRACT: Adolescence represents a crucial period for maturation of brain structures involved in cognition. Early in life unhealthy dietary patterns are associated with inferior cognitive outcomes at later ages; conversely, healthy diet is associated with better cognitive results. In this study we analyzed the effects of a short period of hypercaloric diet on newborn hippocampal doublecortin⁺ (DCX) immature neurons in adolescent mice. Male mice received high fat diet (HFD) or control low fat diet (LFD) from the 5th week of age for 1 or 2 weeks, or 1 week HFD followed by 1 week LFD. After diet supply, mice were either perfused for immunohistochemical (IHC) analysis or their hippocampi were dissected for biochemical assays. Detailed morphometric analysis was performed in DCX⁺ cel

SUBMITTER: Chiazza F 

PROVIDER: S-EPMC8563989 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature