Development and Implementation of In-House Pharmacogenomic Testing Program at a Major Academic Health System.

ABSTRACT: Pharmacogenomics (PGx) studies how a person's genes affect the response to medications and is quickly becoming a significant part of precision medicine. The clinical application of PGx principles has consistently been cited as a major opportunity for improving therapeutic outcomes. Several recent studies have demonstrated that most individuals (> 90%) harbor PGx variants that would be clinically actionable if prescribed a medication relevant to that gene. In multiple well-conducted studies, the results of PGx testing have been shown to guide therapy choice and dosing modifications which improve treatment efficacy and reduce the incidence of adverse drug reactions (ADRs). Although the value of PGx testing is evident, its successful implementation in a clinical setting presents a number of c

SUBMITTER: Mroz P 

PROVIDER: S-EPMC8564018 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature