The cerebellum and its network: Disrupted static and dynamic functional connectivity patterns and cognitive impairment in multiple sclerosis.

ABSTRACT:

Background

The impact of cerebellar damage and (dys)function on cognition remains understudied in multiple sclerosis.

Objective

To assess the cognitive relevance of cerebellar structural damage and functional connectivity (FC) in relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS).

Methods

This study included 149 patients with early RRMS, 81 late RRMS, 48 SPMS and 82 controls. Cerebellar cortical imaging included fractional anisotropy, grey matter volume and resting-state functional magnetic resonance imaging (MRI). Cerebellar FC was assessed with literature-based resting-state networks, using static connectivity (that is, conventional correlations), and dynamic connectivity (that is, fluctuations in FC strength). Measures

SUBMITTER: Schoonheim MM 

PROVIDER: S-EPMC8564243 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature