Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions.

ABSTRACT: Loneliness is a painful condition associated with increased risk for premature mortality. The formation of new, positive social relationships can alleviate feelings of loneliness, but requires rapid trustworthiness decisions during initial encounters and it is still unclear how loneliness hinders interpersonal trust. Here, a multimodal approach including behavioral, psychophysiological, hormonal, and neuroimaging measurements is used to probe a trust-based mechanism underlying impaired social interactions in loneliness. Pre-stratified healthy individuals with high loneliness scores (n = 42 out of a screened sample of 3678 adults) show reduced oxytocinergic and affective responsiveness to a positive conversation, report less interpersonal trust, and prefer larger social distances compared t

SUBMITTER: Lieberz J 

PROVIDER: S-EPMC8564426 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature