Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies.

ABSTRACT: Gluten-specific CD4⁺ T cells being drivers of celiac disease (CeD) are obvious targets for immunotherapy. Little is known about how cell markers harnessed for T-cell-directed therapy can change with time and upon activation in CeD and other autoimmune conditions. In-depth characterization of gluten-specific CD4⁺ T cells and CeD-associated (CD38⁺ and CD103⁺ ) CD8⁺ and γδ⁺ T cells in blood of treated CeD patients undergoing a 3 day gluten challenge is reported. The phenotypic profile of gluten-specific cells changes profoundly with gluten exposure and the cells adopt the profile of gluten-specific cells in untreated disease (CD147⁺ , CD70⁺ , programmed cell death protein 1 (PD-1)⁺ , inducible T

SUBMITTER: Christophersen A 

PROVIDER: S-EPMC8564461 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature