The complex landscape of haematopoietic lineage commitments is encoded in the coarse-grained endogenous network.

ABSTRACT: Haematopoietic lineage commitments are presented by a canonical roadmap in which haematopoietic stem cells or multipotent progenitors (MPPs) bifurcate into progenitors of more restricted lineages and ultimately mature to terminally differentiated cells. Although transcription factors playing significant roles in cell-fate commitments have been extensively studied, integrating such knowledge into the dynamic models to understand the underlying biological mechanism remains challenging. The hypothesis and modelling approach of the endogenous network has been developed previously and tested in various biological processes and is used in the present study of haematopoietic lineage commitments. The endogenous network is constructed based on the key transcription factors and their interactions th

SUBMITTER: Wang M 

PROVIDER: S-EPMC8564612 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature