Resistance Against Leishmania major Infection Depends on Microbiota-Guided Macrophage Activation.

ABSTRACT: Innate immune cells present a dual role during leishmaniasis: they constitute the first line of host defense but are also the main host cells for the parasite. Response against the infection that results in the control of parasite growth and lesion healing depends on activation of macrophages into a classical activated phenotype. We report an essential role for the microbiota in driving macrophage and monocyte-derived macrophage activation towards a resistance phenotype against Leishmania major infection in mice. Both germ-free and dysbiotic mice showed a higher number of myeloid innate cells in lesions and increased number of infected cells, mainly dermal resident and inflammatory macrophages. Despite developing a Th1 immune response characterized by the same levels of IFN-γ produc

SUBMITTER: Lopes ME 

PROVIDER: S-EPMC8564857 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature