Random access DNA memory using Boolean search in an archival file storage system.

ABSTRACT: DNA is an ultrahigh-density storage medium that could meet exponentially growing worldwide demand for archival data storage if DNA synthesis costs declined sufficiently and if random access of files within exabyte-to-yottabyte-scale DNA data pools were feasible. Here, we demonstrate a path to overcome the second barrier by encapsulating data-encoding DNA file sequences within impervious silica capsules that are surface labelled with single-stranded DNA barcodes. Barcodes are chosen to represent file metadata, enabling selection of sets of files with Boolean logic directly, without use of amplification. We demonstrate random access of image files from a prototypical 2-kilobyte image database using fluorescence sorting with selection sensitivity of one in 10⁶ files, which thereby

SUBMITTER: Banal JL 

PROVIDER: S-EPMC8564878 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature