Fronto-temporal functional disconnection precedes hippocampal atrophy in clinically confirmed multi-domain amnestic Mild Cognitive Impairment.

ABSTRACT: Mild Cognitive Impairment (MCI) is fraught with high false positive diagnostic errors. The high rate of false positive diagnosis hampers attempts to identify reliable and valid biomarkers for MCI. Recent research suggests that aberrant functional neurocircuitries emerge prior to significant cognitive deficits. The aim of the present study was to examine this in clinically confirmed multi-domain amnestic-MCI (mdaMCI) using an established, multi-time point, methodology for minimizing false positive diagnosis. Structural and resting-state functional MRI data were acquired in healthy controls (HC, n=24), clinically-confirmed multi-domain amnestic-MCI (mdaMCI, n=14) and mild Alzheimer's Dementia (mAD, n=6). Group differences in cortical thickness, hippocampal volume and functional connectivity

SUBMITTER: Broadhouse KM 

PROVIDER: S-EPMC8564906 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature