Antiproliferative activity of Tamoxifen, Vitamin D3 and their concomitant treatment.

ABSTRACT: Breast cancer stands out as the most common cancer type among women throughout the world. Especially for the estrogen receptor alpha (ER α +) positive breast cancer cells Tamoxifen has been widely used as an anti-cancer agent. Tamoxifen's mechanism of action is through ER. It binds to the receptor and leads to a conformational change which eventually prevents cancer cells proliferation and survival. In our current study, we aimed to investigate the combination of Tamoxifen with Vitamin D₃ to test whether this combination will enhance the anti-cancer effect of Tamoxifen on breast cancer cells in vitro. Vitamin D₃ has sterol structure and this property enables it to act similar to hormones. Vitamin D Receptor (VDR) has been commonly found in different types of ca

SUBMITTER: Yetkin D 

PROVIDER: S-EPMC8564918 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature