Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.

ABSTRACT:

Background

The gut microbiome is altered in patients with inflammatory bowel disease, yet how these alterations contribute to intestinal inflammation is poorly understood. Murine models have demonstrated the importance of the microbiome in colitis since colitis fails to develop in many genetically susceptible animal models when re-derived into germ-free environments. We have previously shown that Wiskott-Aldrich syndrome protein (WASP)-deficient mice (Was^-/-) develop spontaneous colitis, similar to human patients with loss-of-function mutations in WAS. Furthermore, we showed that the development of colitis in Was^-/- mice is Helicobacter dependent. Here, we utilized a reductionist model coupled with multi-omics approaches to study the role of host-microbe inter

SUBMITTER: Tsou AM 

PROVIDER: S-EPMC8565002 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature