Weighted gene co-expression network analysis to identify key modules and hub genes associated with paucigranulocytic asthma.

ABSTRACT:

Background

Asthma is a heterogeneous disease that can be divided into four inflammatory phenotypes: eosinophilic asthma (EA), neutrophilic asthma (NA), mixed granulocytic asthma (MGA), and paucigranulocytic asthma (PGA). While research has mainly focused on EA and NA, the understanding of PGA is limited. In this study, we aimed to identify underlying mechanisms and hub genes of PGA.

Methods

Based on the dataset from Gene Expression Omnibus(GEO), weighted gene coexpression network analysis (WGCNA), differentially expressed genes (DEGs) analysis and protein-protein interaction (PPI) network analysis were conducted to construct a gene network and to identify key gene modules and hub genes. Functional enrichment analyses were performed to investigate the biological process, path

SUBMITTER: Li M 

PROVIDER: S-EPMC8565058 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature