Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study.

ABSTRACT:

Background

Substantial evidence supports an association between physical activity and cognitive function. However, the role of muscle mass and function in brain structural changes is not well known. This study investigated whether sarcopenia, defined as low muscle mass and strength, accelerates brain volume atrophy.

Methods

A total of 1284 participants with sarcopenic measurements and baseline and 4-year follow-up brain magnetic resonance images were recruited from the Korean Genome and Epidemiology Study. Muscle mass was represented as appendicular skeletal muscle mass divided by the body mass index. Muscle function was measured by handgrip strength. The low mass and strength groups were defined as being in the lowest quintile of each variable for one's sex. Sarcopenia was

SUBMITTER: Yu JH 

PROVIDER: S-EPMC8565062 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature