In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood.

ABSTRACT: Metformin is a drug used for the treatment of type 2 diabetes and disorders associated with insulin resistance. Metformin is also used in the treatment of pregnancy disorders such as gestational diabetes. However, the consequences of foetal exposure to metformin on the fertility of exposed offspring remain poorly documented. In this study, we investigated the effect of in utero metformin exposure on the fertility of female and male offspring. We observed that metformin is detectable in the blood of the mother and in amniotic fluid and blood of the umbilical cord. Metformin was not measurable in any tissues of the embryo, including the gonads. The effect of metformin exposure on offspring was sex specific. The adult females that had been exposed to metformin in utero presented

SUBMITTER: Faure MC 

PROVIDER: S-EPMC8565088 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature