Phenylethanoid glycosides as a possible COVID-19 protease inhibitor: a virtual screening approach.

ABSTRACT: From the beginning of pandemic, more than 240 million people have been infected with a death rate higher than 2%. Indeed, the current exit strategy involving the spreading of vaccines must be combined with progress in effective treatment development. This scenario is sadly supported by the vaccine's immune activation time and the inequalities in the global immunization schedule. Bringing the crises under control means providing the world population with accessible and impactful new therapeutics. We screened a natural product library that contains a unique collection of 2370 natural products into the binding site of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M^pro). According to the docking score and to the interaction at the active site, three

SUBMITTER: Bernardi M 

PROVIDER: S-EPMC8565174 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature