Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types.

ABSTRACT: To provide protection against viral infection and limit the uptake of mobile genetic elements, bacteria and archaea have evolved many diverse defence systems. The discovery and application of CRISPR-Cas adaptive immune systems has spurred recent interest in the identification and classification of new types of defence systems. Many new defence systems have recently been reported but there is a lack of accessible tools available to identify homologs of these systems in different genomes. Here, we report the Prokaryotic Antiviral Defence LOCator (PADLOC), a flexible and scalable open-source tool for defence system identification. With PADLOC, defence system genes are identified using HMM-based homologue searches, followed by validation of system completeness using gene presence/absence and s

SUBMITTER: Payne LJ 

PROVIDER: S-EPMC8565338 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature