Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate.
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ABSTRACT:
SUBMITTER: Tao X
PROVIDER: S-EPMC8565384 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate.
Tao Xuan X Zhang Lu L Du Liubing L Liao Ruyan R Cai Huiling H Lu Kai K Zhao Zhennan Z Xie Yanxuan Y Wang Pei-Hui PH Pan Ji-An JA Zhang Yuebin Y Li Guohui G Dai Jun J Mao Zong-Wan ZW Xia Wei W
Chemical science 20210924 42
The SARS-CoV-2 3-chymotrypsin-like protease (3CLpro or Mpro) is a key cysteine protease for viral replication and transcription, making it an attractive target for antiviral therapies to combat the COVID-19 disease. Here, we demonstrate that bismuth drug colloidal bismuth subcitrate (CBS) is a potent inhibitor for 3CLpro <i>in vitro</i> and <i>in cellulo</i>. Rather than targeting the cysteine residue at the catalytic site, CBS binds to an allosteric site and results in dissociation of the 3CLpr ...[more]
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