Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex.

ABSTRACT:

Background

Over the past decade, the number of experimental and clinical studies using theta-burst-stimulation (TBS) protocols of transcranial magnetic stimulation (TMS) to modulate brain activity has risen substantially. The use of TBS is motivated by the assumption that these protocols can reliably and lastingly modulate cortical excitability despite their short duration and low number of stimuli. However, this assumption, and thus the experimental validity of studies using TBS, is challenged by recent work showing large inter- and intra-subject variability in response to TBS protocols.

Objectives

To date, the reproducibility of TBS effects in humans has been exclusively assessed with motor evoked potentials (MEPs), which provide an indirect and limited measure of cortical

SUBMITTER: Ozdemir RA 

PROVIDER: S-EPMC8565400 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature