Elevated serum pentosidine is independently associated with the high prevalence of sarcopenia in Chinese middle-aged and elderly men with type 2 diabetes mellitus.

ABSTRACT:

Aims/introduction

Sarcopenia has recently been recognized as another complication associated with diabetes, but its early screening still lacks clinical markers. Here, we aimed to investigate the relationship between serum levels of pentosidine, which is an advanced glycation end-product, and sarcopenia in Chinese middle-aged and elderly men with type 2 diabetes mellitus and evaluate whether pentosidine could be used as a kind of screening maker.

Materials and methods

A total of 182 male type 2 diabetes mellitus patients aged ≥50 years were selected in the cross-sectional study for whole-body dual-energy X-ray measurement and calculating the appendicular skeletal muscle mass index. At the same time, handgrip strength and gait speed were assessed. According to the updated con

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8565416 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature