Atrophy in Distributed Networks Predicts Cognition in Alzheimer's Disease and Type 2 Diabetes.

ABSTRACT:

Background

Alzheimer's disease (AD) and type 2 diabetes (T2DM) are common causes of cognitive decline among older adults and share strong epidemiological links. Distinct patterns of cortical atrophy are observed in AD and T2DM, but robust comparisons between structure-function relationships across these two disease states are lacking.

Objective

To compare how atrophy within distributed brain networks is related to cognition across the spectrum of cognitive aging.

Methods

The relationship between structural MRI changes and cognition was studied in 22 mild-to-moderate AD, 28 T2DM, and 27 healthy participants. Cortical thickness measurements were obtained from networks of interest (NOIs) matching the limbic, default, and frontoparietal resting-state networks. Composite c

SUBMITTER: Buss SS 

PROVIDER: S-EPMC8565654 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature