Metabolic imaging with hyperpolarized ¹³ C pyruvate magnetic resonance imaging in patients with renal tumors-Initial experience.

ABSTRACT:

Background

Optimal treatment selection for localized renal tumors is challenging because of their variable biologic behavior and limitations in the preoperative assessment of tumor aggressiveness. The authors investigated the emerging hyperpolarized (HP) ¹³ C magnetic resonance imaging (MRI) technique to noninvasively assess tumor lactate production, which is strongly associated with tumor aggressiveness.

Methods

Eleven patients with renal tumors underwent HP ¹³ C pyruvate MRI before surgical resection. Tumor ¹³ C pyruvate and ¹³ C lactate images were acquired dynamically. Five patients underwent 2 scans on the same day to assess the intrapatient reproducibility of HP ¹³ C pyruvate MRI. Tumor metabolic data were compared

SUBMITTER: Tang S 

PROVIDER: S-EPMC8565774 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature