Numerical modelling of blood rheology and platelet activation through a stenosed left coronary artery bifurcation.

ABSTRACT: Coronary bifurcations are prone to atherosclerotic plaque growth, experiencing regions of reduced wall shear stress (WSS) and increased platelet adhesion. This study compares effects across different rheological approaches on hemodynamics, combined with a shear stress exposure history model of platelets within a stenosed porcine bifurcation. Simulations used both single/multiphase blood models to determine which approach best predicts phenomena associated with atherosclerosis and atherothrombosis. A novel Lagrangian platelet tracking model was used to evaluate residence time and shear history of platelets indicating likely regions of thrombus formation. Results show a decrease in area of regions with pathologically low time-averaged WSS with the use of multiphase models, particularly in a

SUBMITTER: Owen DG 

PROVIDER: S-EPMC8565790 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature