The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time.

ABSTRACT: During life, the DNA of our cells is continuously exposed to external damaging processes. Despite the activity of various repair mechanisms, DNA damage eventually results in the accumulation of mutations in the genomes of our cells. Oncogenic mutations are at the root of carcinogenesis, and carcinogenic agents are often highly mutagenic. Over the past decade, whole genome sequencing data of healthy and tumor tissues have revealed how cells in our body gradually accumulate mutations because of exposure to various mutagenic processes. Dissection of mutation profiles based on the type and context specificities of the altered bases has revealed a variety of signatures that reflect past exposure to environmental mutagens, ranging from chemotherapeutic drugs to genotoxic gut bacteria. In this re

SUBMITTER: Rosendahl Huber A 

PROVIDER: S-EPMC8565797 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature