Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons.

ABSTRACT: Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellular mechanisms underlying the maturation of synaptic integration in interneurons, we combined patch-clamp recordings of excitatory inputs in mouse cerebellar stellate cells (SCs), three-dimensional reconstruction of SC morphology with excitatory synapse location, and biophysical modeling. We found that postnatal maturation of postsynaptic strength was homogeneously reduced along the somatodendritic axis, but dendritic integration was always sublinear. However, dendritic branching increased withou

SUBMITTER: Biane C 

PROVIDER: S-EPMC8565927 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature