Neuronal sequences during theta rely on behavior-dependent spatial maps.

ABSTRACT: Navigation through space involves learning and representing relationships between past, current, and future locations. In mammals, this might rely on the hippocampal theta phase code, where in each cycle of the theta oscillation, spatial representations provided by neuronal sequences start behind the animal's true location and then sweep forward. However, the exact relationship between theta phase, represented position and true location remains unclear and even paradoxical. Here, we formalize previous notions of 'spatial' or 'temporal' theta sweeps that have appeared in the literature. We analyze single-cell and population variables in unit recordings from rat CA1 place cells and compare them to model simulations based on each of these schemes. We show that neither spatial nor temporal swe

SUBMITTER: Parra-Barrero E 

PROVIDER: S-EPMC8565928 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature