The Correlation between Gut Microbiota and Serum Metabolomic in Elderly Patients with Chronic Heart Failure.

ABSTRACT:

Objective

Chronic heart failure (CHF) refers to a state of persistent heart failure that can be stable, deteriorated, or decompensated. The mechanism and pathogenesis of myocardial remodeling remain unknown. Based on 16S rDNA sequencing and metabolomics technology, this study analyzed the gut microbiota and serum metabolome in elderly patients with CHF to provide new insights into the microbiota and metabolic phenotypes of CHF.

Methods

Blood and fecal samples were collected from 25 elderly patients with CHF and 25 healthy subjects. The expression of inflammatory factors in blood was detected by ELISA. 16S rDNA sequencing was used to analyze the changes in microorganisms in the samples. The changes of small molecular metabolites in serum samples were analyzed by LC-MS/MS. Spe

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8566067 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature