Alternative polyadenylation: An untapped source for prostate cancer biomarkers and therapeutic targets?

ABSTRACT:

Objective

To review alternative polyadenylation (APA) as a mechanism of gene regulation and consider potential roles for APA in prostate cancer (PCa) biology and treatment.

Methods

An extensive review of mRNA polyadenylation, APA, and PCa literature was performed. This review article introduces APA and its association with human disease, outlines the mechanisms and components of APA, reviews APA in cancer biology, and considers whether APA may contribute to PCa progression and/or produce novel biomarkers and therapeutic targets for PCa.

Results

Eukaryotic mRNA 3'-end cleavage and polyadenylation play a critical role in gene expression. Most human genes encode more than one polyadenylation signal, and produce more than one transcript isoform, through APA. Polyadenylati

SUBMITTER: Kurozumi A 

PROVIDER: S-EPMC8566364 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature