Focal unspecific bone uptake on [¹⁸F]-PSMA-1007 PET: a multicenter retrospective evaluation of the distribution, frequency, and quantitative parameters of a potential pitfall in prostate cancer imaging.

ABSTRACT:

Purpose

Improved logistics and availability led to a rapid increase in the use of [¹⁸F]-PSMA-1007 for prostate cancer PET imaging. Initial data suggests increased uptake in benign lesions compared to [⁶⁸ Ga]-PSMA-11, and clinical observations found increased unspecific bone uptake (UBU). We therefore investigate the frequency and characteristics of UBU in [¹⁸F]-PSMA-1007 PET.

Methods

We retrospectively analyzed [¹⁸F]-PSMA-1007 PET scans from four centers for the presence of UBU, defined as a focal mild-to-moderate uptake (SUV_max < 10.0) not obviously related to a benign or malignant cause. If present, up to three leading UBUs were quantified (SUV_max), localized, and correlated to clinical parameters, such as a

SUBMITTER: Grunig H 

PROVIDER: S-EPMC8566387 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature