Head-to-head comparison of (R)-[¹¹C]verapamil and [¹⁸F]MC225 in non-human primates, tracers for measuring P-glycoprotein function.

ABSTRACT:

Purpose

P-glycoprotein (P-gp) function is altered in several brain disorders; thus, it is of interest to monitor the P-gp function in vivo using PET. (R)-[¹¹C]verapamil is considered the gold standard tracer to measure the P-gp function; however, it presents some drawbacks that limit its use. New P-gp tracers have been developed with improved properties, such as [¹⁸F]MC225. This study compares the characteristics of (R)-[¹¹C]verapamil and [¹⁸F]MC225 in the same subjects.

Methods

Three non-human primates underwent 4 PET scans: 2 with (R)-[¹¹C]verapamil and 2 with [¹⁸F]MC225, at baseline and after P-gp inhibition. The 30-min PET data were analyzed using 1-Tissue Compartment Model (1-TCM) and metabolite-corrected

SUBMITTER: Garcia-Varela L 

PROVIDER: S-EPMC8566421 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature