Where the Aryl Hydrocarbon Receptor Meets the microRNAs: Literature Review of the Last 10 Years.

ABSTRACT: The aryl hydrocarbon receptor (AhR) is an environmentally responsive ligand-activated transcription factor, identified in the '70s for its toxic responses to halogenated polycyclic aromatic hydrocarbons, such as dioxin. Recently, AhR has been recognized as engaged in multiple physiological processes in health and diseases, particularly in the immune system, inflammatory response, tumorigenesis, and cellular differentiation by epigenetic mechanisms involving miRNAs. However, there is still scarce information about AhR-dependent miRNA regulation and miRNA-mediated epigenetic control in pathologies and therapies. In this review, we explore the mutual regulation of AhR and miRNA over the last decade of studies since many miRNAs have dioxin response elements (DRE) in their 3' UTR, as well as Ah

SUBMITTER: Disner GR 

PROVIDER: S-EPMC8566438 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature