The sooner the better: clinical and neural correlates of impulsive choice in Tourette disorder.

ABSTRACT: Reward sensitivity has been suggested as one of the central pathophysiological mechanisms in Tourette disorder. However, the subjective valuation of a reward by introduction of delay has received little attention in Tourette disorder, even though it has been suggested as a trans-diagnostic feature of numerous neuropsychiatric disorders. We aimed to assess delay discounting in Tourette disorder and to identify its brain functional correlates. We evaluated delayed discounting and its brain functional correlates in a large group of 54 Tourette disorder patients and 31 healthy controls using a data-driven approach. We identified a subgroup of 29 patients with steeper reward discounting, characterised by a higher burden of impulse-control disorders and a higher level of general impulsivity comp

SUBMITTER: Atkinson-Clement C 

PROVIDER: S-EPMC8566507 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature