Interleukin-2 PET imaging in patients with metastatic melanoma before and during immune checkpoint inhibitor therapy.

ABSTRACT:

Purpose

Immune checkpoint inhibitors can induce a T cell-mediated anti-tumor immune response in patients with melanoma. Visualizing T cell activity using positron emission tomography (PET) might allow early insight into treatment efficacy. Activated tumor-infiltrating T cells express the high-affinity interleukin-2 receptor (IL-2R). Therefore, we performed a pilot study, using fluorine-18-labeled IL-2 ([¹⁸F]FB-IL2 PET), to evaluate whether a treatment-induced immune response can be detected.

Methods

Patients with metastatic melanoma received ~ 200 MBq [¹⁸F]FB-IL2 intravenously, followed by a PET/CT scan before and during immune checkpoint inhibitor therapy. [¹⁸F]FB-IL2 uptake was measured as standardized uptake value in healthy tissues (SUV

SUBMITTER: van de Donk PP 

PROVIDER: S-EPMC8566634 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature