Prediction of TERTp-mutation status in IDH-wildtype high-grade gliomas using pre-treatment dynamic [¹⁸F]FET PET radiomics.

ABSTRACT:

Purpose

To evaluate radiomic features extracted from standard static images (20-40 min p.i.), early summation images (5-15 min p.i.), and dynamic [¹⁸F]FET PET images for the prediction of TERTp-mutation status in patients with IDH-wildtype high-grade glioma.

Methods

A total of 159 patients (median age 60.2 years, range 19-82 years) with newly diagnosed IDH-wildtype diffuse astrocytic glioma (WHO grade III or IV) and dynamic [¹⁸F]FET PET prior to surgical intervention were enrolled and divided into a training (n = 112) and a testing cohort (n = 47) randomly. First-order, shape, and texture radiomic features were extracted from standard static (20-40 min summation images; TBR_20-40), early static (5-15 min summation images; TBR_5-15),

SUBMITTER: Li Z 

PROVIDER: S-EPMC8566644 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature