Stilbene compounds are specific inhibitors of the superoxide anion generation catalyzed by xanthine oxidase.

ABSTRACT: The inhibitory effect of xanthine oxidase (XO) reactions with stilbene compounds, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging by stilbene compounds and superoxide anion (O₂-) scavenging activity were examined. The inhibition of the O₂- generation catalyzed by XO by stilbene compounds is stronger than the effect on uric acid formation. The suppression of the O₂- generation with resveratrol was diminished by the addition of flavin adenine dinucleotide (FAD). The water-solubility and visible spectra (VIS) of the stilbene compounds in the presence of water-soluble flavin compounds indicated a π-π interaction between the stilbene compounds and the isoalloxazine in flavin compounds. These results indicate that stilbene compounds specifically bind the FAD site

SUBMITTER: Masuoka N 

PROVIDER: S-EPMC8566757 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature