DeepREx-WS: A web server for characterising protein-solvent interaction starting from sequence.

ABSTRACT: Protein-solvent interaction provides important features for protein surface engineering when the structure is absent or partially solved. Presently, we can integrate the notion of solvent exposed/buried residues with that of their flexibility and intrinsic disorder to highlight regions where mutations may increase or decrease protein stability in order to modify proteins for biotechnological reasons, while preserving their functional integrity. Here we describe a web server, which provides the unique possibility of integrating knowledge of solvent and non-solvent exposure with that of residue conservation, flexibility and disorder of a protein sequence, for a better understanding of which regions are relevant for protein integrity. The core of the webserver is DeepREx, a novel deep learnin

SUBMITTER: Manfredi M 

PROVIDER: S-EPMC8566768 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature