High mucosal cytomegalovirus DNA helps predict adverse short-term outcome in acute severe ulcerative colitis.

ABSTRACT:

Background/aims

Predictors of short-term outcome of intravenous (IV) steroid therapy in acute severe ulcerative colitis (ASUC) have been well described, but the impact of cytomegalovirus (CMV) infection as a predictor of outcome remains debatable. We investigated the role of quantitative CMV polymerase chain reaction (PCR) as a predictor of short-term outcome in patients with ASUC.

Methods

Consecutive patients with ASUC satisfying Truelove and Witts criteria hospitalized at All India Institute of Medical Sciences (AIIMS) from May 2016 to July 2019 were included; all received IV steroid. The primary outcome measure was steroid-failure defined as the need for rescue therapy (with ciclosporin or infliximab) or colectomy during admission. AIIMS' index (ulcerative colitis index o

SUBMITTER: Jain S 

PROVIDER: S-EPMC8566826 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature