DNA Methylation Patterns in CD8⁺ T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity.

ABSTRACT: Background: Psoriasis is a T cell-mediated chronic autoimmune/inflammatory disease. While some patients experience disease limited to the skin (skin psoriasis), others develop joint involvement (psoriatic arthritis; PsA). In the absence of disease- and/or outcome-specific biomarkers, and as arthritis can precede skin manifestations, diagnostic and therapeutic delays are common and contribute to disease burden and damage accrual. Objective: Altered epigenetic marks, including DNA methylation, contribute to effector T cell phenotypes and altered cytokine expression in autoimmune/inflammatory diseases. This project aimed at the identification of disease-/outcome-specific DNA methylation signatures in CD8⁺ T cells from patients with psoriasis and PsA as compared to hea

SUBMITTER: Charras A 

PROVIDER: S-EPMC8567019 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature