Lipid raft-disrupting miltefosine preferentially induces the death of colorectal cancer stem-like cells.

ABSTRACT:

Background

Lipid rafts (LRs), cholesterol-enriched microdomains on cell membranes, are increasingly viewed as signalling platforms governing critical facets of cancer progression. The phenotype of cancer stem-like cells (CSCs) presents significant hurdles for successful cancer treatment, and the expression of several CSC markers is associated with LR integrity. However, LR implications in CSCs remain unclear.

Methods

This study evaluated the biological and molecular functions of LRs in colorectal cancer (CRC) by using an LR-disrupting alkylphospholipid (APL) drug, miltefosine. The mechanistic role of miltefosine in CSC inhibition was examined through normal or tumour intestinal mouse organoid, human CRC cell, CRC xenograft and miltefosine treatment gene expression profile an

SUBMITTER: Park SY 

PROVIDER: S-EPMC8567043 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature