Immune Response of Neonates Born to Mothers Infected With SARS-CoV-2.

ABSTRACT:

Importance

Although several studies have provided information on short-term clinical outcomes in children with perinatal exposure to SARS-CoV-2, data on the immune response in the first months of life among newborns exposed to the virus in utero are lacking.

Objective

To characterize systemic and mucosal antibody production during the first 2 months of life among infants who were born to mothers infected with SARS-CoV-2.

Design, setting, and participants

This prospective cohort study enrolled 28 pregnant women who tested positive for SARS-CoV-2 infection and who gave birth at Policlinico Umberto I in Rome, Italy, from November 2020 to May 2021, and their newborns. Maternal and neonatal systemic immune responses were investigated by detecting spike-specific antibodies

SUBMITTER: Conti MG 

PROVIDER: S-EPMC8567114 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature